PAC | Protein & Cell 最新文章欢迎阅览

论文标题：Protein & Cell Issue 10 of 2022 is released!

期刊：Protein Cell

(资料图片仅供参考)

微信链接：点击此处阅读微信文章

COVER STORY:Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies for improving the efficiency of germ cell production in vitro. Shi et al. developed a coupled screening strategy that took advantage of an arrayed BiFC platform for protein-protein interaction screens and EpiLC-induction assays using reporter mESCs. Investigation of candidate interaction partners of core human pluripotent factors OCT4, NANOG, KLF4 and SOX2 in EpiLC differentiation assays identified novel primordial germ cell (PGC)-inducing factors including BEN-domain (BEND/ Bend) family members. Through RNA-seq, ChIP-seq, and ATAC-seq analyses, the authors showed that Bend5 worked together with Bend4 and helped mark chromatin boundaries to promote EpiLC induction in vitro. These suggest that BEND/Bend proteins represent a new family of transcriptional modulators and chromatin boundary factors that participate in gene expression regulation during early germline development.

Recollection

Darwinian rebel: The legacy of Loh-Seng Tsai—Chinese animal psychologist

Yong Wang, Wei Chen, Shiying Li, Bin Yin

Review

New pathogenic insights from large animal models of neurodegenerative diseases

Peng Yin, Shihua Li, Xiao-Jiang Li, Weili Yang

Research Articles

Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation

Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang

Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis

Yuting Wang, Liping Liu, Yifan Song, Xiaojie Yu, Hongkui Deng

8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI

Linhua Tai, Yun Zhu, He Ren, Xiaojun Huang, Chuanmao Zhang, Fei Sun

Contact us: protein_cell@mail.biols.ac.cn

《前沿》系列英文学术期刊

由教育部主管、高等教育出版社主办的《前沿》（Frontiers）系列英文学术期刊，于2006年正式创刊，以网络版和印刷版向全球发行。系列期刊包括基础科学、生命科学、工程技术和人文社会科学四个主题，是我国覆盖学科最广泛的英文学术期刊群，其中13种被SCI收录，其他也被A&HCI、Ei、MEDLINE或相应学科国际权威检索系统收录，具有一定的国际学术影响力。系列期刊采用在线优先出版方式，保证文章以最快速度发表。

中国学术前沿期刊网

http://journal.hep.com.cn

来源：Protein Cell

版权声明：本文转载仅仅是出于传播信息的需要，并不意味着代表本网站观点或证实其内容的真实性；如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任；作者如果不希望被转载或者联系转载稿费等事宜，请与我们接洽。